Aquaporin 8 antibody (Intracellular, N-Term)

Catalog No. ABIN7884772

The Rabbit Polyclonal anti-Aquaporin 8 antibody is suitable to detect Aquaporin 8 in samples from Mouse. It has been validated for WB and IHC.

Quick Overview for Aquaporin 8 antibody (Intracellular, N-Term) (ABIN7884772)

Target: Aquaporin 8 (AQP8)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aquaporin 8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-Aquaporin 8 Antibody

Binding Specificity: AA 14-28, Intracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Aquaporin 8 Channel

Predicted Reactivity: Unlikely to recognize mouse,human samples

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)REIKGKETNMADSYH, corresponding to amino acid residues 14-28 of rat AQP8

Isotype: IgG

Application Details

Application Notes:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7234779)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Aquaporin 8

Target: Aquaporin 8 (AQP8)

Alternative Name: AQP8

Background:

Synonyms: AQP8

Description: Aquaporin 8 (AQP-8) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes.1 The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12.The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are permeated primarily by water and include besides AQP-8, AQP-1, AQP-2, AQP4 and AQP-5, and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3, AQP-7, AQP-9 and AQP-10.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.2AQP-8 is expressed along the gastrointestinal tract including small intestine, colon, pancreas and liver and also in other organs such as testis, lung and kidney.The physiological function of AQP-8 is not entirely clear but studies suggest that it has an important role in colonic water adsorption and hepatocyte bile formation.3,4 Interestingly, AQP-8 expression is markedly altered in gastrointestinal disorders such as ulcerative colitis and inflammatory bowel disease.5

Gene ID: 29172

UniProt: P56405