Chloride Channel 5 antibody (Extracellular)

Catalog No. ABIN7884875

The Rabbit Polyclonal anti-Chloride Channel 5 antibody (ABIN7884875) specifically detects Chloride Channel 5 in WB and IHC. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Chloride Channel 5 antibody (Extracellular) (ABIN7884875)

Target: Chloride Channel 5 (CLCN5)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chloride Channel 5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-Chloride Channel 5 Antibody

Binding Specificity: AA 401-415, Extracellular

Purpose: A Rabbit Polyclonal Antibody to CLC-5 (CLCN5) Channel

Predicted Reactivity: Mouse - identical, human - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: CDYENHFNTSKGGEL, corresponding to amino acid residues 401-415 of rat CLCN5 

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235090)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Chloride Channel 5

Target: Chloride Channel 5 (CLCN5)

Alternative Name: CLCN5

Background:

Synonyms: CLCN5, Chloride channel 5, Chloride transporter ClC-5, H+/Cl- exchange transporter 5, DENTS

Description: CLC5 is a member of the voltage-dependent Cl- channel family that includes nine known members. Based on sequence similarity, CLC5 is closely linked to the CLC3 and CLC4 subunits. CLC-5 is mainly found in intracellular vesicles, particularly in early endosomes, where it is believed to contribute to their acidification.The channel is mainly expressed in the kidney, although it has also been found in the small intestine, brain and liver.Mutations in the CLC5 gene cause Dent's disease, an X-linked renal disorder.

Gene ID: 25749

UniProt: P51796