GPR174 antibody (Extracellular Loop)

Catalog No. ABIN7884975

This Rabbit Polyclonal antibody specifically detects GPR174 in WB, FACS and LCI. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GPR174 antibody (Extracellular Loop) (ABIN7884975)

Target: GPR174 (G Protein-Coupled Receptor 174 (GPR174))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR174 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-GPR174 Antibody

Binding Specificity: AA 160-175, Extracellular Loop

Purpose: A Rabbit Polyclonal Antibody to GPR174

Predicted Reactivity: Human - 15,16 amino acid residues identical, mouse,rat - 13

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DTSGNRTK(S)FVDLPTR, corresponding to amino acid residues 160 - 175 of human GPR174

Isotype: IgG

Application Details

Application Notes:

WB: 1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235384)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for GPR174

Target: GPR174 (G Protein-Coupled Receptor 174 (GPR174))

Alternative Name: G-protein coupled receptor 174

Background:

Synonyms: G-protein coupled receptor 174, LYPSR3, GPCR17, FKSG79

Description: GPR174 (LysoPS, LYPSR3), is one of three lysophosphatidyl serine receptors, belonging to the superfamily of G-protein coupled receptors. Lysophospholipids are a diverse group of small, membrane-derived phospholipids that act as extracellular signals1.Activation of GPR174 leads to an increase in cAMP cellular levels, leading to cellular morphological changes, cell to cell adhesion, and delays in cell proliferation2.GPR174 is reported to be a genetic risk locus for Graves disease, an autoimmune disorder that causes hyperthyroidism3 and as a negative regulator of T-cells activation4.

Gene ID: 84636

UniProt: Q9BXC1