GAP43 antibody (C-Term)

Catalog No. ABIN7885073

The Rabbit Polyclonal anti-GAP43 antibody (ABIN7885073) specifically detects GAP43 in WB, IHC and IF. The antibody is reactive with Rat and Mouse samples.

Quick Overview for GAP43 antibody (C-Term) (ABIN7885073)

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAP43 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-GAP43 Antibody

Binding Specificity: AA 205-218, C-Term

Purpose: A Rabbit Polyclonal Antibody to GAP43

Predicted Reactivity: Mouse - identical, human - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)KPKESARQDEGKED, corresponding to amino acid residues 205-218 of rat GAP43

Isotype: IgG

Application Details

Application Notes:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235735)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for GAP43

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Alternative Name: Axonal membrane protein GAP-43

Background:

Synonyms: Axonal membrane protein GAP-43, Growth-associated protein 43, Neuromodulin, Neural phosphoprotein B-50

Description: Growth associated protein 43 (GAP43) is a neuron specific phosphoprotein that plays an important role in the process of nerve growth, development, regeneration and axonal remodeling. GAP43 belongs to the calmodulin-binding protein family and is highly distributed in the presynaptic membrane1.GAP43 is expressed in developing neurons, especially in the growth cone. In mature neurons, GAP43 is detected in regenerating nerves. In brain injury, neurons exhibit sprouting of the lateral branches and responsive regeneration of the axon accompanied by increased expression of GAP43. GAP43 expression is used as an important tool for evaluating axon injury and the regenerative response in the mature central nervous system (CNS)1,2.

Gene ID: 29423

UniProt: P07936