LYNX1 antibody (Extracellular, N-Term)

Catalog No. ABIN7885120

The Rabbit Polyclonal anti-LYNX1 antibody is suitable to detect LYNX1 in samples from Mouse, Human and Rat. It has been validated for WB, FACS, IF and IHC.

Quick Overview for LYNX1 antibody (Extracellular, N-Term) (ABIN7885120)

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LYNX1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-LYNX1 Antibody

Binding Specificity: AA 26-38, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Lynx1

Predicted Reactivity: rat - 12,Mouse,13 amino acid residues identical, human - 11

Purification: Affinity purified on immobilized antigen.

Immunogen: CAYNGDN(S)FKPMR, corresponding to amino acid residues 26-38 of mouse Lynx1

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1000

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235894)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for LYNX1

Target: LYNX1 (Ly6/Neurotoxin 1 (LYNX1))

Alternative Name: Ly-6/Neurotoxin-like protein 1

Background:

Synonyms: Ly-6/Neurotoxin-like protein 1, Endogenous prototoxin LYNX1

Description: Lynx1 is a member of the Ly-6/neurotoxin gene superfamily (Lynx family) of proteins that feature a three-looped toxin fold and a cysteine rich motif, structural characteristics that are shared with the snake venom toxin α-bungarotoxin1.Lynx1 is expressed in large projection neurons in the hippocampus, cortex, and cerebellum. Initial analysis of the functional consequence of genetic ablation of Lynx1 in mice revealed that Lynx1 is an allosteric modulator of various nicotinic receptors that affects their kinetics, decreases their agonist affinities, and increases their desensitization to overall limit their activation. Lynx1 can serve as a protective measure against neurotoxicity through agonist-induced overstimulation2. In fact, deletion of Lynx1 eventually leads to neurodegeneration in aged mice3.Collectively the findings regarding Lynx1 suggest a direct relationship between plasticity regulation and nicotinic signaling, and underline the significance of fine tuning of nicotinic tone to vastly control the development of brain functions.Lynx1 activity was shown to be related to the pathophysiology of Alzheimer's disease as well as cholinergic activity in healthy and tumor cells of bronchial epithelium4.

Gene ID: 23936

UniProt: P0DP60