NPTXR antibody (C-Term, Extracellular)

Catalog No. ABIN7885179

This Rabbit Polyclonal antibody specifically detects NPTXR in WB, IHC, FACS and LCI. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NPTXR antibody (C-Term, Extracellular) (ABIN7885179)

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPTXR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-NPTXR Antibody

Binding Specificity: AA 162-176, C-Term, Extracellular

Purpose: A Rabbit Polyclonal Antibody to NPTXR (extracellular)

Predicted Reactivity: Rat - identical, human - 14 out of 15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR 

Isotype: IgG

Application Details

Application Notes:

WB: 1:400

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:1200

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236082)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for NPTXR

Target: NPTXR (Neuronal Pentraxin Receptor (NPTXR))

Alternative Name: NPR

Background:

Synonyms: NPR, NPTXR

Description: Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer's disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.

Gene ID: 73340

UniProt: Q99J85