PLXNB1 antibody (Extracellular, N-Term)

Catalog No. ABIN7885237

The Rabbit Polyclonal anti-PLXNB1 antibody is suitable to detect PLXNB1 in samples from Human, Mouse and Rat. It has been validated for WB, IHC and FACS.

Quick Overview for PLXNB1 antibody (Extracellular, N-Term) (ABIN7885237)

Target: PLXNB1 (Plexin B1 (PLXNB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLXNB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-PLXNB1 Antibody

Binding Specificity: AA 1159-1174, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Plexin-B1 (extracellular)

Predicted Reactivity: Human - identical. Rat - 13 out of 16 amino acid residues identical.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DPKVHSIFPARGPRAG, corresponding to amino acid residues 1159 - 1174 of mouse Plexin-B1

Isotype: IgG

Application Details

Application Notes: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for PLXNB1

Target: PLXNB1 (Plexin B1 (PLXNB1))

Alternative Name: PLXNB1

Background:

Synonyms: Semaphorin receptor SEP, PLXNB1

Description:

Plexin-B1 is a transmembrane receptor that belongs to the plexin family, a group of proteins best known for their role in semaphorin signaling. As a receptor for Class IV semaphorins, particularly Semaphorin 4D (Sema4D) and Semaphorin 4A (Sema4A), Plexin-B1 regulates diverse biological functions including cytoskeletal remodeling, cell adhesion, and migration. Given this broad range of interactions, Plexin-B1 has become recognized as a critical regulator in neural development, immune response, and cancer biology.1

In the central nervous system, Plexin-B1 plays a pivotal role in axonal guidance and synapse formation. The receptor-ligand interactions with both Sema4D and Sema4A deliver directional signals that influence neural wiring. Notably, these ligands can provide either attractive or repulsive cues, depending on cellular context.1

Beyond its developmental functions, Plexin-B1 contributes to neuroinflammatory processes. In experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis, the Sema4D-Plexin-B1 interaction promotes microglial activation and the release of nitric oxide, exacerbating neuronal damage.2

Plexin-B1 is also widely expressed in the immune system, where it contributes to immune cell communication and migration. Both Sema4D and Sema4A are important ligands in this context. Sema4A, like Sema4D, is expressed on activated T cells and antigen-presenting cells. When it binds to Plexin-B1, it modulates T-cell activation and can influence cytokine production and immune tolerance. This dual-ligand functionality expands the scope of Plexin-B1's involvement in both innate and adaptive immune responses. Together, these interactions underscore Plexin-B1's central role in orchestrating immune dynamics and maintaining immune homeostasis.3,4

Aberrant Plexin-B1 expression and signaling are frequently observed in cancer, where they contribute to tumor progression and metastasis. Overexpression of Plexin-B1 has been documented in several cancers, including prostate, pancreatic, and skin carcinomas, often correlating with increased invasiveness and poor prognosis.5,6

Gene ID: 235611

UniProt: Q8CJH3