SCTR antibody (Extracellular, N-Term)

Catalog No. ABIN7885379

The Rabbit Polyclonal anti-SCTR antibody (ABIN7885379) specifically detects SCTR in WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SCTR antibody (Extracellular, N-Term) (ABIN7885379)

Target: SCTR (Secretin Receptor (SCTR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCTR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-SCTR Antibody

Binding Specificity: AA 129-143, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Secretin Receptor

Predicted Reactivity: 15 amino acid residues identical,Mouse - 14, human - 12

Purification: Affinity purified on immobilized antigen.

Immunogen: Peptide (C)NSFNERRHAYLLKLK, corresponding to amino acid residues 129 - 143 of rat Secretin Receptor

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236749)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for SCTR

Target: SCTR (Secretin Receptor (SCTR))

Alternative Name: SCTR

Background:

Synonyms: SCTR

Description: Secretin receptor, SCTR, binds Secretin, a hormone that affects water homeostasis throughout the body and specifically in the duodenum of the small intestine.SCTR is ubiquitously expressed throughout the body. It belongs to class B1 of G-protein coupled receptors, along with vasoactive intestinal polypeptide (VIP) receptor. Like all G-protein coupled receptors, it is composed of seven highly conserved transmembrane domains1. The amino terminus of Secretin receptor plays a key role in agonist recognition and responsiveness2.The binding of SCTR to Secretin initiates a signaling cascade that stimulates bicarbonate secretion which in turn leads to neutralization of gastric H+. This process plays an essential role in fat digestion by creating a more neutral ( pH 6 to 8) environment. Secretin levels are regulated by H+ and fatty acids levels in the duodenum and hence the secretion regulation is tightly bound to its activity3.In addition, SCTR-Secretin interaction plays a major role in the regulation of the secretory activity in the heart, liver and the central nervous system (CNS)3.

Gene ID: 6344

UniProt: P23811