Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) antibody

Catalog No. ABIN7885404

This Rabbit Polyclonal antibody specifically detects Sodium Channel-Pan in IF, IHC, WB, IC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) antibody (ABIN7885404)

Target: Sodium Channel-Pan

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB), Immunochromatography (IC), Immunoprecipitation (IP)

Grade: Carrier-free

Product Details

Binding Specificity: AA 1501-1518, Intracellular Loop

Purpose: A Rabbit Polyclonal Antibody to Pan NaV Channel

Predicted Reactivity: The epitope is identical in all isoforms of NaV1 in all vertebrates,and highly homologous in molluscan,insect voltage-gated Na+ channels

Purification: Affinity purified on immobilized antigen.

Immunogen: TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat NaV1.1

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details

Target: Sodium Channel-Pan

Alternative Name: Pan sodium channel

Background:

Synonyms: Pan sodium channel, SP19

Description: Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7

Gene ID: 81574

UniProt: P04774