SSTR2 antibody (Extracellular, N-Term)

Catalog No. ABIN7885527

This Rabbit Polyclonal antibody specifically detects SSTR2 in WB, IHC, FACS, IF, LCI and IC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for SSTR2 antibody (Extracellular, N-Term) (ABIN7885527)

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI), Immunochromatography (IC)

Grade: Carrier-free

Product Details anti-SSTR2 Antibody

Binding Specificity: AA 30-43, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2

Predicted Reactivity: Mouse - identical, human- 12,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)GSNQTEPYYDMTSN, corresponding to amino acid residues 30-43 of rat SSTR2

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: 5 mg per reaction

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237239)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Alternative Name: SSTR2

Background:

Synonyms: SSTR2, SS2R, Smstr2, SRIF1A

Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner.1,2Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner.2Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors.4In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.

Gene ID: 54305

UniProt: P30680