SSTR3 antibody (Intracellular)

Catalog No. ABIN7885529

The Rabbit Polyclonal anti-SSTR3 antibody (ABIN7885529) specifically detects SSTR3 in WB, IHC and IF. The antibody is reactive with Rat and Mouse samples.

Quick Overview for SSTR3 antibody (Intracellular) (ABIN7885529)

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSTR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-SSTR3 Antibody

Binding Specificity: AA 233-246, Intracellular

Purpose: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 3

Predicted Reactivity: Mouse - identical, human - 11,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: KVRSTTRRVRAPSC, corresponding to amino acid residues 233-246 of rat SSTR3

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237243)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for SSTR3

Target: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Alternative Name: SSTR3

Background:

Synonyms: SSTR3, SS3R, Smstr3

Description: Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. SST induces in target cells a variety of physiological functions that include nueromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that are originated form five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. Thus, SSTR3 expression in the brain is primarily concentrated in the cerebellum with lesser expression in peripheral organs such as the spleen, the liver and the pituitary.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.

Gene ID: 171044

UniProt: P30936