TACR2 antibody (Intracellular, N-Term)

Catalog No. ABIN7885567

The Rabbit Polyclonal anti-TACR2 antibody is suitable to detect TACR2 in samples from Rat and Mouse. It has been validated for WB and IHC.

Quick Overview for TACR2 antibody (Intracellular, N-Term) (ABIN7885567)

Target: TACR2 (Tachykinin Receptor 2 (TACR2))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-TACR2 Antibody

Binding Specificity: AA 351-367, Intracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Neurokinin 2 Receptor

Predicted Reactivity: Mouse - identical, human - 13,17 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: CHTKETLFMTGDMTHSE, corresponding to amino acid residues 351-367 of rat NK2 receptor

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237373)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for TACR2

Target: TACR2 (Tachykinin Receptor 2 (TACR2))

Alternative Name: NK2 receptor

Background:

Synonyms: NK2 receptor, Neurokinin A receptor, Tachykinin receptor 2, TACR2, Substance-K receptor, SKR

Description: Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides, which demonstrate quite a heterogeneity in their distribution, exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 (NK1) receptor preferentially binds Substance P, Neurokinin 2 (NK2) receptor to NKA, and Neurokinin 3 (NK3) receptor to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 receptor is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 receptor is widely expressed in neurons, endothelial cells, muscle and immune system cells. NK2 receptor is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 receptor on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.

Gene ID: 25007

UniProt: P16610

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion