TMEM38B antibody (Cytoplasmic Loop, Intracellular)

Catalog No. ABIN7885622

The Rabbit Polyclonal anti-TMEM38B antibody (ABIN7885622) specifically detects TMEM38B in WB, IHC and IC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TMEM38B antibody (Cytoplasmic Loop, Intracellular) (ABIN7885622)

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM38B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Grade: Carrier-free

Product Details anti-TMEM38B Antibody

Binding Specificity: AA 116-126, Cytoplasmic Loop, Intracellular

Purpose: A Rabbit Polyclonal Antibody to TRIC-B Channel

Predicted Reactivity: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)GMKEVTRTWKIVG, corresponding to amino acid residues 116-126 of rat TRIC-B

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237524)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for TMEM38B

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Alternative Name: Trimeric intracellular cation channel type B

Background:

Synonyms: Trimeric intracellular cation channel type B, Transmembrane protein 38B

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

Gene ID: 362521

UniProt: Q68FV1