UTS2R antibody (2nd Cytoplasmic Loop)

Catalog No. ABIN7885632

This Rabbit Polyclonal antibody specifically detects UTS2R in WB and IHC. It exhibits reactivity toward Mouse.

Quick Overview for UTS2R antibody (2nd Cytoplasmic Loop) (ABIN7885632)

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UTS2R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-UTS2R Antibody

Binding Specificity: 2nd Cytoplasmic Loop, AA 154-167

Purpose: A Rabbit Ployclonal Antibody to Urotensin II Receptor

Predicted Reactivity: Bovine - identical, human,canine - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat URIIR

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237551)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for UTS2R

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Alternative Name: Urotensin 2 receptor

Background:

Synonyms: Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14

Description: Urotensin II is a powerful vasoconstrictive substance. The human urotensin II receptor (UR-II-R) was originally isolated as an orphan receptor (GPR14) from neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues such as the CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5 Binding of urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that urotensin II is also expressed in various kinds of tumor cells such as adrenal tumors and neuroblastomas. In those cells, urotensin II was reported to stimulate cell growth.7-9

Gene ID: 57305

UniProt: P49684