DPPA2 antibody

Catalog No. ABIN7938108

This Rabbit Polyclonal antibody specifically detects DPPA2 in WB. It exhibits reactivity toward Human.

Quick Overview for DPPA2 antibody (ABIN7938108)

Target: DPPA2 (Developmental Pluripotency Associated 2 (DPPA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPPA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DPPA2 Antibody

Purpose: DPPA2 antibody (pAb)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against a peptide corresponding to DPPA2.

Isotype: IgG

Application Details

Application Notes: WB: 0.5 μg/mL-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: PBS containing 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for DPPA2

Target: DPPA2 (Developmental Pluripotency Associated 2 (DPPA2))

Alternative Name: DPPA2

Background:

Background_Plain: DPPA2 and DPPA4 (developmental pluripotency associated 2 and 4) are small heterodimerizing nuclear proteins linked in the biological processes of transcription and transcription regulation. The encoded proteins have a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. The nuclear factor encoded by the gene is involved in the maintenance of pluripotency in stem cells and is found to be essential for embryogenesis. DPPA2 and DPPA4 are required to maintain H3K4me3 and H3K27me3 at important bivalent promoters depicted in pluripotent cells by low H3K4me3 levels and initiating but not elongating RNA polymerase II. This gene is thought to play an important role in tumor progression because when mutated it is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers.

Aliases: Developmental Pluripotency Associated 2

Molecular Weight: 32 kDa

NCBI Accession: NP_620170

Pathways: Stem Cell Maintenance