Recombinant CBX5 antibody

Catalog No. ABIN7938268

This Rabbit Monoclonal antibody specifically detects CBX5 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant CBX5 antibody (ABIN7938268)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CBX5 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 240145F11

Product Details anti-CBX5 Antibody

Purpose: HP1 antibody (rAb), 100 μg (Clone 240145F11)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the HP1 fusion protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Alternative Name: HP1

Background:

Background_Plain: HP1 (Heterochromatin protein 1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (a, b and g) occur in mammals. The chromodomain (Chromatin Organization Modifier) of HP1a is responsible for binding to Histone H3 methyl Lys9, although additional factors are required to specify the HP1 targeting. The chromoshadow domain mediates interactions with a number of nuclear proteins, including SuvH39 (a Histone H3 Lysine methyltransferase), the DNA methyltransferases DNMT1 and DNMT3A or the large subunit of the chromatin assembly factor-1 (CAF-1). Dysfunction of HP1a plays a critical role in tumorigenesis, and is implicated in the invasive/metastatic phenotype of breast cancer.

Aliases: CBX5, HP1, Hp1a

Molecular Weight: 22 kDa