Recombinant KAT5 antibody

Catalog No. ABIN7938310

This Rabbit Monoclonal antibody specifically detects KAT5 in IF. It exhibits reactivity toward Human.

Quick Overview for Recombinant KAT5 antibody (ABIN7938310)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This KAT5 antibody is un-conjugated

Application: Immunofluorescence (IF)

Clone: 230181D5

Product Details anti-KAT5 Antibody

Purpose: KAT5 antibody (rAb), 100 μg (Clone 230181D5)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the KAT5 fusion protein.

Isotype: IgG

Application Details

Application Notes: IF: 1:200-1:800 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Alternative Name: KAT5

Background:

Background_Plain: KAT5 (K(Lysine) Acetyltransferase 5) is the atalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Aliases: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1

Molecular Weight: 60 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway