KDM2B antibody

Catalog No. ABIN7938317

The Mouse Monoclonal anti-KDM2B antibody is suitable to detect KDM2B in samples from Human and Mouse. It has been validated for WB.

Quick Overview for KDM2B antibody (ABIN7938317)

Target: KDM2B (Lysine (K)-Specific Demethylase 2B (KDM2B))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KDM2B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: K2K842-13

Product Details anti-KDM2B Antibody

Purpose: KDM2B antibody (mAb) (Clone K2K842-13)

Purification: Protein A Chromatography

Immunogen: This KDM2B antibody was raised against a peptide containing human lysine-specific demethylase 2B of isoform a.

Isotype: IgG

Application Details

Application Notes: WB: 0.5 - 2 μg/mL dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for KDM2B

Target: KDM2B (Lysine (K)-Specific Demethylase 2B (KDM2B))

Alternative Name: KDM2B

Background:

Background_Plain: KDM2B (lysine (K)-specific demethylase 2B), also known as FBXL10 (F-box and leucine-rich repeat protein 10) is a histone demethylase that preferentially demethylates trimethylated lysine 4 (K4me3) and dimethylated lysine 36 (K36me2) of histone H3. KDM2B displays weak or no activity for mono- and trimethylated H3K36. KDM2B preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which results in inhibition of cell growth and proliferation. KDM2B may also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Aliases: FBXL10

Molecular Weight: 100 kDa

NCBI Accession: NP_115979

Pathways: Tube Formation, Warburg Effect