TRIM37 antibody (C-Term)

Catalog No. ABIN7938530

The Rabbit Polyclonal anti-TRIM37 antibody is suitable to detect TRIM37 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for TRIM37 antibody (C-Term) (ABIN7938530)

Target: TRIM37 (Tripartite Motif Containing 37 (TRIM37))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM37 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIM37 Antibody

Binding Specificity: C-Term

Purpose: TRIM37 antibody (pAb), sample

Purification: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human TRIM37.

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2,000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for TRIM37

Target: TRIM37 (Tripartite Motif Containing 37 (TRIM37))

Alternative Name: TRIM37

Background:

Background_Plain: TRIM37 (Tripartite Motif Containing 37) is an E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724).

Aliases: MUL, POB1, TEF3

Molecular Weight: 120 kDa

NCBI Accession: NP_056109