Recombinant VCP antibody

Catalog No. ABIN7938537

The Rabbit Monoclonal anti-VCP antibody (Clone 3G23) (ABIN7938537) specifically detects VCP in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant VCP antibody (ABIN7938537)

Target: VCP (Valosin Containing Protein (VCP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This VCP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3G23

Product Details anti-VCP Antibody

Purpose: VCP antibody (rAb), 100 μg (Clone 3G23)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the VCP fusion protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution IHC: 1:50-1:500 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for VCP

Target: VCP (Valosin Containing Protein (VCP))

Alternative Name: VCP

Background:

Background_Plain: VCP (Valosin-containing protein), also known as TER ATPase and 15S Mg2+-ATPase p97 subunit, belongs to the AAA ATPase family. VCP was first identified as a result of attempts to clone a putative peptide hormone called valosin. It was found that the cloned cDNA encoded a ubiquitously expressed 90 kDa cytosolic protein, termed VCP, which showed none of the characteristics of a peptide hormone precursor. Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia (ALS14).

Aliases: Valosin-containing protein

Molecular Weight: 89 kDa

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway