ABAT antibody (AA 388-500) (Cy3)

Catalog No. ABIN7965023

The Rabbit Polyclonal anti-ABAT antibody is suitable to detect ABAT in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for ABAT antibody (AA 388-500) (Cy3) (ABIN7965023)

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABAT antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-ABAT Antibody (Cy3)

Binding Specificity: AA 388-500

Purpose: Anti-ABAT Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human ABAT recombinant protein (Position: K388-K500). Human ABAT shares 93.9%,94.5% amino acid (aa) sequence identity with mouse,rat ABAT,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human ABAT recombinant protein (Position: K388-K500). Human ABAT shares 93.9% and 94.5% amino acid (aa) sequence identity with mouse and rat ABAT, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Alternative Name: ABAT

Background:

Background: 4-Aminobutyrate aminotransferase is a protein that in humans is encoded by the ABAT gene. ABAT is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5- phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of humans ynapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractoryseizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Gene Full Name: 4-aminobutyrate aminotransferase

Sequence Similarities: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.

Gene ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process