XRN1 antibody (AA 523-1198) (PE)

Catalog No. ABIN7965140

The Rabbit Polyclonal anti-XRN1 antibody is suitable to detect XRN1 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for XRN1 antibody (AA 523-1198) (PE) (ABIN7965140)

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-XRN1 Antibody (PE)

Binding Specificity: AA 523-1198

Purpose: Anti-XRN1 Antibody PE Conjugated

Predicted Reactivity: Human XRN1 shares 93.2% amino acid (aa) sequence identity with mouse XRN1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human XRN1 recombinant protein (Position: K523-H1198). Human XRN1 shares 93.2% amino acid (aa) sequence identity with mouse XRN1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for XRN1

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Alternative Name: XRN1

Background:

Background: 5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts ly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.

Gene Full Name: 5'-3' exoribonuclease 1

Gene ID: 54464

UniProt: Q8IZH2