NT5DC3 antibody (AA 52-548) (Cy3)

Catalog No. ABIN7965166

This Rabbit Polyclonal antibody specifically detects NT5DC3 in FACS. It exhibits reactivity toward Human.

Quick Overview for NT5DC3 antibody (AA 52-548) (Cy3) (ABIN7965166)

Target: NT5DC3 (5'-Nucleotidase Domain Containing 3 (NT5DC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NT5DC3 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-NT5DC3 Antibody (Cy3)

Binding Specificity: AA 52-548

Purpose: Anti-NT5DC3 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NT5DC3 recombinant protein (Position: D52-K548).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NT5DC3

Target: NT5DC3 (5'-Nucleotidase Domain Containing 3 (NT5DC3))

Alternative Name: NT5DC3

Background:

Background: 5'-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins. NT5DC2 shows high sequence similarity with NT5C2. NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine, a drug frequently used to treat hematological neoplasms. NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool. Therefore, NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity. NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts, while NT5DC2 knockdown inhibits these processes. NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder. NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis. NT5DC2 has been shown to interact with and stabilize Fyn, an Src family proto-oncogene, and plays a role in regulating glioblastoma progression.

Gene Full Name: 5'-nucleotidase domain containing 3

Gene ID: 51559

UniProt: Q86UY8