PFKFB1 antibody (AA 12-186) (Fluoro594)

Catalog No. ABIN7965224

The Rabbit Polyclonal anti-PFKFB1 antibody is suitable to detect PFKFB1 in samples from Human. It has been validated for FACS.

Quick Overview for PFKFB1 antibody (AA 12-186) (Fluoro594) (ABIN7965224)

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKFB1 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-PFKFB1 Antibody (Fluoro594)

Binding Specificity: AA 12-186

Purpose: Anti-PFKFB1 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PFKFB1 recombinant protein (Position: R12-R186).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for PFKFB1

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Alternative Name: PFKFB1

Background:

Background: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Gene ID: 5207

UniProt: P16118

Pathways: Regulation of Carbohydrate Metabolic Process