APRT antibody (C-Term) (Fluoro488)

Catalog No. ABIN7966597

This Rabbit Polyclonal antibody specifically detects APRT in FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for APRT antibody (C-Term) (Fluoro488) (ABIN7966597)

Target: APRT (Adenine Phosphoribosyltransferase (APRT))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APRT antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-APRT Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-Aprt Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse APRT, which shares 86.4% and 95.5% amino acid (aa) sequence identity with human and rat APRT, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for APRT

Target: APRT (Adenine Phosphoribosyltransferase (APRT))

Alternative Name: Aprt

Background:

Background: Adenine phosphoribosyltransferase (APRTase) is anenzymeencoded by theAPRTgene, found inhumanson chromosome 16. It belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: adenine phosphoribosyl transferase

Gene ID: 11821

UniProt: P08030

Pathways: Ribonucleoside Biosynthetic Process