alpha Fetoprotein antibody (AA 378-609) (Fluoro488)

Catalog No. ABIN7967917

This Rabbit Polyclonal antibody specifically detects alpha Fetoprotein in FACS. It exhibits reactivity toward Human.

Quick Overview for alpha Fetoprotein antibody (AA 378-609) (Fluoro488) (ABIN7967917)

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Fetoprotein antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-alpha Fetoprotein Antibody (Fluoro488)

Binding Specificity: AA 378-609

Purpose: Anti-alpha 1 Fetoprotein/AFP Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human AFP shares 71%,73% amino acid (aa) sequences identity with mouse,rat AFP,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human AFP recombinant protein (Position: Q378-V609). Human AFP shares 71% and 73% amino acid (aa) sequences identity with mouse and rat AFP, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for alpha Fetoprotein

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Alternative Name: AFP

Background:

Background: AFP, also called Alpha-fetoprotein, alpha-fetoprotein, is a protein that in humans is encoded by the AFP gene. It is mapped to 4q13.3. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. In rodents AFP binds estradiol to prevent the transport of this hormone across the placenta to the fetus. The main function of this is to prevent the virilization of female fetuses. Moreover, it has an important role as a diagnostic marker, especially in certain tumors and liver diseases of childhood. AFP is also used to test the potential usefulness of plasma alpha fetoprotein determination as a diagnostic marker in biliary atresia, hepatitis, and yolk sac derived tumours.

Gene Full Name: alpha fetoprotein

Sequence Similarities: Belongs to the ALB/AFP/VDB family.

Gene ID: 174

UniProt: P02771

Pathways: C21-Steroid Hormone Metabolic Process