ANAPC5 antibody (AA 1-266) (Fluoro647)

Catalog No. ABIN7968375

The Fluoro647-conjugated Rabbit Polyclonal anti-ANAPC5 antibody (ABIN7968375) specifically detects ANAPC5 in FACS. The antibody is reactive with Human samples.

Quick Overview for ANAPC5 antibody (AA 1-266) (Fluoro647) (ABIN7968375)

Target: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC5 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-ANAPC5 Antibody (Fluoro647)

Binding Specificity: AA 1-266

Purpose: Anti-Apc5/ANAPC5 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Apc5/ANAPC5 recombinant protein (Position: M1-D266).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ANAPC5

Target: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Alternative Name: ANAPC5

Background:

Background: Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.

Gene Full Name: anaphase promoting complex subunit 5

Gene ID: 51433

UniProt: Q9UJX4

Pathways: M Phase