AANAT antibody (AA 24-205) (Biotin)

Catalog No. ABIN7969884

This Rabbit Polyclonal antibody specifically detects AANAT in ELISA, WB and IHC. It exhibits reactivity toward Mouse.

Quick Overview for AANAT antibody (AA 24-205) (Biotin) (ABIN7969884)

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AANAT antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-AANAT Antibody (Biotin)

Binding Specificity: AA 24-205

Purpose: Anti-Aanat Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Aanat recombinant protein (Position: C24-C205).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for AANAT

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Alternative Name: Aanat

Background:

Background: Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.

Gene Full Name: arylalkylamine N-acetyltransferase

Gene ID: 11298

UniProt: O88816

Pathways: Photoperiodism