AANAT antibody (AA 24-205) (Cy3)

Catalog No. ABIN7969885

The Rabbit Polyclonal anti-AANAT antibody is suitable to detect AANAT in samples from Mouse. It has been validated for FACS.

Quick Overview for AANAT antibody (AA 24-205) (Cy3) (ABIN7969885)

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AANAT antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-AANAT Antibody (Cy3)

Binding Specificity: AA 24-205

Purpose: Anti-Aanat Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Aanat recombinant protein (Position: C24-C205).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for AANAT

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Alternative Name: Aanat

Background:

Background: Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants.

Gene Full Name: arylalkylamine N-acetyltransferase

Gene ID: 11298

UniProt: O88816

Pathways: Photoperiodism