AIRE antibody (AA 1-120) (Fluoro594)

Catalog No. ABIN7971596

The Fluoro594-conjugated Rabbit Polyclonal anti-AIRE antibody (ABIN7971596) specifically detects AIRE in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for AIRE antibody (AA 1-120) (Fluoro594) (ABIN7971596)

Target: AIRE (Autoimmune Regulator (AIRE))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIRE antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-AIRE Antibody (Fluoro594)

Binding Specificity: AA 1-120

Purpose: Anti-AIRE Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human AIRE shares 87.2% amino acid (aa) sequence identity with mouse AIRE.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human AIRE recombinant protein (Position: M1-K120). Human AIRE shares 87.2% amino acid (aa) sequence identity with mouse AIRE.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for AIRE

Target: AIRE (Autoimmune Regulator (AIRE))

Alternative Name: AIRE

Background:

Background: The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Gene Full Name: autoimmune regulator

Gene ID: 326

UniProt: O43918

Pathways: Chromatin Binding