AXIN2 antibody (AA 614-843) (APC)

Catalog No. ABIN7971721

The Rabbit Polyclonal anti-AXIN2 antibody is suitable to detect AXIN2 in samples from Human. It has been validated for FACS.

Quick Overview for AXIN2 antibody (AA 614-843) (APC) (ABIN7971721)

Target: AXIN2 (Axin 2 (AXIN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXIN2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-AXIN2 Antibody (APC)

Binding Specificity: AA 614-843

Purpose: Anti-Axin 2/AXIN2 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Axin 2/AXIN2 recombinant protein (Position: D614-D843).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Alternative Name: AXIN2

Background:

Background: Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Gene Full Name: axin 2

Gene ID: 8313

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling