BIK antibody (AA 1-123) (FITC)

Catalog No. ABIN7972414

The Rabbit Polyclonal anti-BIK antibody is suitable to detect BIK in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for BIK antibody (AA 1-123) (FITC) (ABIN7972414)

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIK antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-BIK Antibody (FITC)

Binding Specificity: AA 1-123

Purpose: Anti-Bik Antibody FITC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human Bik shares 42.3% amino acid (aa) sequence identity with mouse Bik.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Bik recombinant protein (Position: M1-R123). Human Bik shares 42.3% amino acid (aa) sequence identity with mouse Bik.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for BIK

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Alternative Name: BIK

Background:

Background: Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene. This gene is mapped to 22q13.31. The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

Gene Full Name: BCL2 interacting killer

Gene ID: 638

UniProt: Q13323

Pathways: Positive Regulation of Endopeptidase Activity