Calpain 3 antibody (AA 42-764) (APC)

Catalog No. ABIN7974365

The APC-conjugated Rabbit Polyclonal anti-Calpain 3 antibody (ABIN7974365) specifically detects Calpain 3 in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for Calpain 3 antibody (AA 42-764) (APC) (ABIN7974365)

Target: Calpain 3 (CAPN3)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 3 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-Calpain 3 Antibody (APC)

Binding Specificity: AA 42-764

Purpose: Anti-Calpain 3/CAPN3 Antibody APC Conjugated

Predicted Reactivity: Human CAPN3 shares 93.5%,94.2% amino acid (aa) sequence identity with mouse,rat CAPN3,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Calpain 3/CAPN3 recombinant protein (Position: I42-D764). Human CAPN3 shares 93.5% and 94.2% amino acid (aa) sequence identity with mouse and rat CAPN3, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Calpain 3

Target: Calpain 3 (CAPN3)

Alternative Name: Calpain 3/CAPN3

Background:

Background: Calpain-3 is a protein that in humans is encoded by the CAPN3 gene. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Gene Full Name: calpain 3

Gene ID: 825

UniProt: P20807

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development