Calpain 6 antibody (AA 1-641) (Biotin)

Catalog No. ABIN7974380

The Biotin-conjugated Rabbit Polyclonal anti-Calpain 6 antibody (ABIN7974380) specifically detects Calpain 6 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Calpain 6 antibody (AA 1-641) (Biotin) (ABIN7974380)

Target: Calpain 6 (CAPN6)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 6 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Calpain 6 Antibody (Biotin)

Binding Specificity: AA 1-641

Purpose: Anti-Calpain 6/CAPN6 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Calpain 6,CAPN6 shares 95.2%,95% amino acid (aa) sequence identity with mouse,rat Calpain 6,CAPN6,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Calpain 6/CAPN6 recombinant protein (Position: M1-L641). Human Calpain 6/CAPN6 shares 95.2% and 95% amino acid (aa) sequence identity with mouse and rat Calpain 6/CAPN6, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Calpain 6

Target: Calpain 6 (CAPN6)

Alternative Name: CAPN6

Background:

Background: Calpain-6 (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Gene Full Name: calpain 6

Gene ID: 827

UniProt: Q9Y6Q1