Calpastatin antibody (Middle Region) (HRP)

Catalog No. ABIN7974397

The Rabbit Polyclonal anti-Calpastatin antibody is suitable to detect Calpastatin in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for Calpastatin antibody (Middle Region) (HRP) (ABIN7974397)

Target: Calpastatin (CAST)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpastatin antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Calpastatin Antibody (HRP)

Binding Specificity: Middle Region

Purpose: Anti-Calpastatin/CAST Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by fifteen amino acids,and from the related rat sequence by eleven amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Calpastatin, different from the related mouse sequence by fifteen amino acids, and from the related rat sequence by eleven amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Calpastatin

Target: Calpastatin (CAST)

Alternative Name: CAST

Background:

Background: Calpastatin is a protein that in humans is encoded by the CAST gene. It is mapped to 5q15. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Full Name: calpastatin

Gene ID: 831

UniProt: P20810