CREB3 antibody (AA 1-352) (Biotin)

Catalog No. ABIN7974490

The Rabbit Polyclonal anti-CREB3 antibody is suitable to detect CREB3 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for CREB3 antibody (AA 1-352) (Biotin) (ABIN7974490)

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CREB3 Antibody (Biotin)

Binding Specificity: AA 1-352

Purpose: Anti-CREB3 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human CREB3 shares 67.1% amino acid (aa) sequence identity with mouse CREB3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CREB3 recombinant protein (Position: M1-K352). Human CREB3 shares 67.1% amino acid (aa) sequence identity with mouse CREB3.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CREB3

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Alternative Name: CREB3

Background:

Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Gene Full Name: cAMP responsive element binding protein 3

Gene ID: 10488

UniProt: O43889

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response