CTSC antibody (AA 22-463) (APC)

Catalog No. ABIN7975829

The APC-conjugated Rabbit Polyclonal anti-CTSC antibody (ABIN7975829) specifically detects CTSC in FACS. The antibody is reactive with Human samples.

Quick Overview for CTSC antibody (AA 22-463) (APC) (ABIN7975829)

Target: CTSC (Cathepsin C (CTSC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTSC antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-CTSC Antibody (APC)

Binding Specificity: AA 22-463

Purpose: Anti-CTSC Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CTSC recombinant protein (Position: V22-L463).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CTSC

Target: CTSC (Cathepsin C (CTSC))

Alternative Name: CTSC

Background:

Background: Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene. This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

Gene Full Name: cathepsin C

Gene ID: 1075

UniProt: P53634