Cathepsin F antibody (Middle Region) (Fluoro647)

Catalog No. ABIN7975897

The Rabbit Polyclonal anti-Cathepsin F antibody is suitable to detect Cathepsin F in samples from Human. It has been validated for FACS.

Quick Overview for Cathepsin F antibody (Middle Region) (Fluoro647) (ABIN7975897)

Target: Cathepsin F (CTSF)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin F antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Cathepsin F Antibody (Fluoro647)

Binding Specificity: Middle Region

Purpose: Anti-Cathepsin F/CTSF Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Cathepsin F/CTSF, which shares 69.6% amino acid (aa) sequence identity with both mouse Cathepsin F/CTSF.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cathepsin F

Target: Cathepsin F (CTSF)

Alternative Name: CTSF

Background:

Background: Cathepsin F is a protein that in humans is encoded by the CTSF gene. Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.

Gene Full Name: cathepsin F

Gene ID: 8722

UniProt: Q9UBX1