Cathepsin K antibody (AA 115-329) (PE)

Catalog No. ABIN7975940

The PE-conjugated Rabbit Polyclonal anti-Cathepsin K antibody (ABIN7975940) specifically detects Cathepsin K in FACS. The antibody is reactive with Human samples.

Quick Overview for Cathepsin K antibody (AA 115-329) (PE) (ABIN7975940)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Cathepsin K Antibody (PE)

Binding Specificity: AA 115-329

Purpose: Anti-Cathepsin K/CTSK Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9%,88.8% amino acid (aa) sequence identity with mouse,rat Cathepsin K,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: CTSK

Background:

Background: Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin,?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Gene Full Name: cathepsin K

Gene ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades