CD276 antibody (AA 29-458) (APC)

Catalog No. ABIN7976643

This Rabbit Polyclonal antibody specifically detects CD276 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD276 antibody (AA 29-458) (APC) (ABIN7976643)

Target: CD276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-CD276 Antibody (APC)

Binding Specificity: AA 29-458

Purpose: Anti-CD276 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CD276 recombinant protein (Position: L29-Q458).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background:

Background: Cluster of Differentiation 276 (CD276) or B7 Homolog 3 (B7-H3) is a human protein encoded by the CD276 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: CD276 Molecule

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints