CD3D antibody (AA 22-171) (Fluoro488)

Catalog No. ABIN7976792

The Fluoro488-conjugated Rabbit Polyclonal anti-CD3D antibody (ABIN7976792) specifically detects CD3D in FACS. The antibody is reactive with Human samples.

Quick Overview for CD3D antibody (AA 22-171) (Fluoro488) (ABIN7976792)

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD3D antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-CD3D Antibody (Fluoro488)

Binding Specificity: AA 22-171

Purpose: Anti-CD3D Antibody Fluoro488 Conjugated

Predicted Reactivity: Human CD3D shares 66%,70.7% amino acid (aa) sequence identity with mouse,rat CD3D,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CD3D recombinant protein (Position: F22-K171). Human CD3D shares 66% and 70.7% amino acid (aa) sequence identity with mouse and rat CD3D, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CD3D

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Alternative Name: CD3D

Background:

Background: T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene. The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

Gene Full Name: CD3 delta subunit of T-cell receptor complex

Gene ID: 915

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events