Ceruloplasmin antibody (AA 20-259)

Catalog No. ABIN7978231

The Rabbit Polyclonal anti-Ceruloplasmin antibody is suitable to detect Ceruloplasmin in samples from Human. It has been validated for WB and FACS.

Quick Overview for Ceruloplasmin antibody (AA 20-259) (ABIN7978231)

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ceruloplasmin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-Ceruloplasmin Antibody

Binding Specificity: AA 20-259

Purpose: Anti-Ceruloplasmin/CP Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human Ceruloplasmin recombinant protein (Position: K20-M259). Human Ceruloplasmin shares 80.8%,79.6% amino acid (aa) sequence identity with mouse,rat Ceruloplasmin,respectively.

Characteristics: Anti-Ceruloplasmin/CP Antibody. Tested in Flow Cytometry, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Ceruloplasmin recombinant protein (Position: K20-M259). Human Ceruloplasmin shares 80.8% and 79.6% amino acid (aa) sequence identity with mouse and rat Ceruloplasmin, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Ceruloplasmin

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Alternative Name: CP

Background:

Background: Ceruloplasmin  (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. It is mapped to 3q23-q25. The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II)transferrin to Fe (III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Gene Full Name: ceruloplasmin

Molecular Weight: 122 kDa

Gene ID: 1356

UniProt: P00450

Pathways: Transition Metal Ion Homeostasis