CCL4 antibody (AA 24-92)

Catalog No. ABIN7978727

The Rabbit Polyclonal anti-CCL4 antibody (ABIN7978727) specifically detects CCL4 in WB and IHC. The antibody is reactive with Rat samples.

Quick Overview for CCL4 antibody (AA 24-92) (ABIN7978727)

Target: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Product Details anti-CCL4 Antibody

Binding Specificity: AA 24-92

Purpose: Anti-Macrophage Inflammatory Protein 1 beta/CCL4 Antibody

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Rat CCL4 shares 80%,86% amino acid (aa) sequences identity with human,mouse CCL4,respectively.

Characteristics: Anti-Macrophage Inflammatory Protein 1 beta/CCL4 Antibody. Tested in IHC, WB applications. This antibody reacts with Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat CCL4 recombinant protein (Position: A24-N92). Rat CCL4 shares 80% and 86% amino acid (aa) sequences identity with human and mouse CCL4, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Rat

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCL4

Target: CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))

Alternative Name: CCL4

Background:

Background: Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in human is encoded by the CCL4 gene. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize CCL4. Based on functional analysis of CCL4, one or more additional beta chemokine receptors that transduce CCL4 signals must also exist. MIP-1alpha and CCL4 have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many alpha as well as beta chemokines (11, 14).

Gene Full Name: C-C motif chemokine ligand 4

Sequence Similarities: Belongs to the Wnt family.

Molecular Weight: 36 kDa

Gene ID: 116637

UniProt: P50230