CCR6 antibody (C-Term) (Cy3)

Catalog No. ABIN7979026

The Rabbit Polyclonal anti-CCR6 antibody is suitable to detect CCR6 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for CCR6 antibody (C-Term) (Cy3) (ABIN7979026)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR6 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-CCR6 Antibody (Cy3)

Binding Specificity: C-Term

Purpose: Anti-CCR6/CCR6 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat,mouse sequences by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CCR6, different from the related rat and mouse sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CCR6

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Alternative Name: CCR6

Background:

Background: CCR6, also termed CKRL3, encodes a 369-amino acid polypeptide with greatest similarity to the family of alpha-chemokine-binding receptors. Unlike most chemokine receptor genes, it is encoded by more than 1 exon. Weakly expressed as a 4-kb transcript in spleen, lymph nodes, peripheral blood lymphocytes and appendix, CCR6 gene is located at 6q27. As the receptor for MIP-3-alpha, its activation leads to phospholipase C-dependent intracellular Ca (2+) mobilization. Additionally, CCR6 are markedly upregulated in psoriasis.

Gene Full Name: C-C motif chemokine receptor 6

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene ID: 1235

UniProt: P51684

Pathways: cAMP Metabolic Process