CXCR2 antibody (Middle Region) (HRP)

Catalog No. ABIN7979295

This Rabbit Polyclonal antibody specifically detects CXCR2 in WB, IHC and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for CXCR2 antibody (Middle Region) (HRP) (ABIN7979295)

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CXCR2 Antibody (HRP)

Binding Specificity: Middle Region

Purpose: Anti-CXCR2 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by six amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CXCR2, different from the related mouse sequence by six amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Alternative Name: CXCR2

Background:

Background: CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.

Gene Full Name: C-X-C motif chemokine receptor 2

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene ID: 3579

UniProt: P25025

Pathways: cAMP Metabolic Process