CXCR6 antibody (C-Term) (Fluoro488)

Catalog No. ABIN7979423

The Fluoro488-conjugated Rabbit Polyclonal anti-CXCR6 antibody (ABIN7979423) specifically detects CXCR6 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for CXCR6 antibody (C-Term) (Fluoro488) (ABIN7979423)

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR6 antibody is conjugated to Fluoro488

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CXCR6 Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-Bonzo/CXCR6 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse,rat sequences by three amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo, different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Mouse, Rat
1. Kim, C. H., Kunkel, E. J., Boisvert, J., Johnston, B., Campbell, J. J., Genovese, M. C., Greenberg, H. B., Butcher, E. C. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J. Clin. Invest. 107: 595-601, 2001. 2. Liao, F., Alkhatib, G., Peden, K. W. C., Sharma, G., Berger, E. A., Farber, J. M. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185: 2015-2023, 1997. 3. Matloubian, M., David, A., Engel, S., Ryan, J. E., Cyster, J. G. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nature Immun. 1: 298-304, 2000.

Comment:

Applications are recommended based on the unconjugated antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CXCR6

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Alternative Name: CXCR6

Background:

Background: CXCR6 (Chemokine,CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al. (2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.

Gene Full Name: C-X-C motif chemokine receptor 6

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene ID: 10663

UniProt: O00574