CLCN3 antibody (AA 293-752) (Fluoro594)

Catalog No. ABIN7979535

This Rabbit Polyclonal antibody specifically detects CLCN3 in FACS. It exhibits reactivity toward Rat and Human.

Quick Overview for CLCN3 antibody (AA 293-752) (Fluoro594) (ABIN7979535)

Target: CLCN3 (Chloride Channel 3 (CLCN3))

Reactivity: Rat, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCN3 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-CLCN3 Antibody (Fluoro594)

Binding Specificity: AA 293-752

Purpose: Anti-CLCN3 Antibody Fluoro594 Conjugated

Predicted Reactivity: Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CLCN3 recombinant protein (Position: G293-R752). Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CLCN3

Target: CLCN3 (Chloride Channel 3 (CLCN3))

Alternative Name: CLCN3

Background:

Background: H+/Cl? exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Full Name: chloride voltage-gated channel 3

Gene ID: 1182

UniProt: P51790