Chromogranin A antibody (N-Term) (Fluoro488)

Catalog No. ABIN7979907

This Rabbit Polyclonal antibody specifically detects Chromogranin A in FACS. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Chromogranin A antibody (N-Term) (Fluoro488) (ABIN7979907)

Target: Chromogranin A (CHGA)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chromogranin A antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Chromogranin A Antibody (Fluoro488)

Binding Specificity: N-Term

Purpose: Anti-Chromogranin A/Chga Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of rat Chromogranin A/Chga, which shares 77.8% and 100% amino acid (aa) sequence identity with human and mouse CHGA, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Chromogranin A

Target: Chromogranin A (CHGA)

Alternative Name: Chga

Background:

Background: CHGA, also known as CGA or chromogranin A, is an acidic protein costored and coreleased with catecholamines from storage granules in the adrenal medulla. CHGA is a member of the granin family of neuroendocrine secretory protein, It is located in secretory vesicles of neurons and endocrine cells. In humans, CHGA protein is encoded by the CHGA gene, and it is mapped to 14q32.12. CHGA gene product is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine).

Gene Full Name: chromogranin A

Gene ID: 24258

UniProt: P10354

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling