C10orf2 antibody (AA 39-635) (Fluoro550)

Catalog No. ABIN7979974

The Rabbit Polyclonal anti-C10orf2 antibody is suitable to detect C10orf2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for C10orf2 antibody (AA 39-635) (Fluoro550) (ABIN7979974)

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C10orf2 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-C10orf2 Antibody (Fluoro550)

Binding Specificity: AA 39-635

Purpose: Anti-Twinkle/TWNK Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human Twinkle,TWNK shares 87.8% amino acid (aa) sequence identity with mouse Twinkle,TWNK.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Twinkle/TWNK recombinant protein (Position: R39-K635). Human Twinkle/TWNK shares 87.8% amino acid (aa) sequence identity with mouse Twinkle/TWNK.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for C10orf2

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Alternative Name: TWNK

Background:

Background: This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: twinkle mtDNA helicase

Gene ID: 56652

UniProt: Q96RR1