C4orf49 antibody (AA 1-155) (HRP)

Catalog No. ABIN7980109

The Rabbit Polyclonal anti-C4orf49 antibody is suitable to detect C4orf49 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for C4orf49 antibody (AA 1-155) (HRP) (ABIN7980109)

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4orf49 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-C4orf49 Antibody (HRP)

Binding Specificity: AA 1-155

Purpose: Anti-MGARP Antibody HRP Conjugated

Predicted Reactivity: Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C4orf49

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Alternative Name: MGARP

Background:

Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Gene Full Name: mitochondria localized glutamic acid rich protein

Gene ID: 84709

UniProt: Q8TDB4